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An overview of Skp2: a promising new therapeutic target of psoriasis

Yashika Tomar1, Moushumi Baidya2, Jay Chadokiya1

  • 1Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science (BITS), Pilani, India.

Expert Opinion on Therapeutic Targets
|August 1, 2024
PubMed
Abstract

Insights

S-phase kinase-associated protein 2 (Skp2) is a promising therapeutic target for psoriasis. Modulating Skp2 may help manage this chronic immune disorder by addressing inflammation and cell proliferation.

Area of Science:

  • Dermatology
  • Immunology
  • Molecular Biology

Background:

  • Psoriasis is a chronic immune-mediated disorder affecting millions globally, impacting quality of life.
  • Current treatments face challenges with recurrence and potential cancer risks.
  • Key pathways involve IL-17, TNF-α, and JAK-STAT signaling.

Purpose of the Study:

  • To explore S-phase kinase-associated protein 2 (Skp2) as a novel therapeutic target for psoriasis.
  • To review the role of Skp2 in psoriasis pathophysiology and its potential for intervention.

Main Methods:

  • Review of current literature on psoriasis pathophysiology.
  • Analysis of Skp2's role in cell cycle regulation, angiogenesis, and ubiquitin pathways.
  • Discussion of emerging therapeutic strategies targeting Skp2.

Main Results:

  • Skp2 is implicated in cell cycle regulation, angiogenesis, and ubiquitin-mediated processes relevant to psoriasis.
  • Modulating Skp2 activity offers a potential avenue for therapeutic intervention.

Conclusions:

  • Targeting Skp2 presents a promising strategy for novel psoriasis therapies.
  • Further research on Skp2 inhibitors is essential for clinical application in psoriasis management.
Keywords:
AngiogenesisS-phase kinase-associated protein 2 (Skp2)inflammatory signaling pathwayskeratinocyte proliferationpsoriasis

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