Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Policy pathways and historical insights: Canada's evolving approach to psychedelic access for end-of-life distress.

The International journal on drug policy·2026

Same author

Examining associations between patient experience and post-treatment recovery outcomes among individuals who completed an inpatient addiction treatment program.

Journal of substance use and addiction treatment·2026

Same author

Making sense of desperation for treatment in decisions to use psychedelics for depression and anxiety: A qualitative Subreddit study anticipating clinical challenges.

General hospital psychiatry·2026

Same author

Characterizing clinical heterogeneity in an inpatient service treating mental, substance use and concurrent disorders.

PLOS mental health·2026

Same author

Indigenous Knowledge Systems & Psychedelic Science: Towards Ethical and Reciprocal Collaboration.

Journal of psychopharmacology (Oxford, England)·2026

Same author

A scoping review of variations in psychedelic interventions for psychological suffering associated with the end of life.

Social science & medicine (1982)·2025

Search research articles

Related Experiment Video

Updated: Jun 18, 2025

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Using Latent Profile Analysis to Characterize Clinical Heterogeneity and Impulsivity in a Large Residential Addiction

Marie N S Gendy^1,2,3, Shannon Remers^3,4, Andriy V Samokhvalov^2,3,5

¹Peter Boris Centre for Addictions Research, St. Joseph's Healthcare, McMaster University, Hamilton, Canada.

Substance Use & Misuse

|August 1, 2024

Summary

Identifying patient subgroups in addiction treatment is key. Five distinct profiles emerged, varying in substance use and psychiatric severity, informing personalized care for better outcomes.

Keywords:

LPA SUD addiction mental health psychiatric comorbidities

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

A Conflict Model of Reward-seeking Behavior in Male Rats

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Related Experiment Videos

Last Updated: Jun 18, 2025

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

A Conflict Model of Reward-seeking Behavior in Male Rats

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Area of Science:

Addiction Medicine
Psychiatry
Data Science

Background:

Clinical heterogeneity in substance use disorder (SUD) treatment poses challenges.
Standardized treatments may not meet individual patient needs.
Tailored approaches are needed to improve treatment outcomes.

Purpose of the Study:

To systematically characterize clinical heterogeneity in patients with SUD.
To identify distinct patient profiles based on substance use and co-occurring psychiatric conditions.
To inform the development of personalized addiction treatment strategies.

Main Methods:

Latent profile analysis (LPA) was used.
Data from 1519 inpatient SUD treatment patients (April 2018-March 2020).
Clustering based on substance use, depression, anxiety, and PTSD severity.

Main Results:

Five distinct patient profiles were identified.
Profiles varied in SUD severity, psychiatric comorbidities, and age.
Higher psychiatric severity was observed in alcohol and cannabis-focused profiles.
Impulsive behavior was higher in polysubstance and high-severity cannabis/psychiatric profiles.

Conclusions:

LPA effectively identified five patient clusters with significant heterogeneity.
Tailored treatment pathways addressing specific profile needs are recommended.
Personalized approaches focusing on commonalities within clusters can enhance SUD treatment effectiveness.