Related Experiment Video
Updated: Jun 18, 2025
08:42
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
Published on: November 21, 2023
1.1K
PATHOPHYSIOLOGY OF POSTTRAUMATIC ANKLE OSTEOARTHRITIS: A MULTICENTER PERSPECTIVE
Alexandre Leme Godoy-Santos1,2, Cesar de Cesar3, Simone Santini4
1Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas HC-FMUSP, Laboratório Prof Manlio Mario Marco Napoli, São Paulo, SP, Brazil.
Acta Ortopedica Brasileira
|August 1, 2024
Summary
Post-traumatic ankle osteoarthritis (PTOA) involves complex molecular and tissue changes. Understanding these interconnected factors is crucial for effective treatment, as targeting single molecules may not halt disease progression.
Area of Science:
- Orthopedics
- Molecular Biology
- Pathophysiology
Background:
- Post-traumatic ankle osteoarthritis (PTOA) develops from acute injury, involving tissue and molecular changes.
- Molecular pathway alterations impact chondrocyte viability, influencing PTOA progression.
- Innovative treatments are emerging for focal PTOA.
Purpose of the Study:
- To enhance medical awareness of PTOA.
- To present scientific evidence on PTOA pathophysiology, molecular biology, and treatment.
Main Methods:
- Literature review adhering to PRISMA guidelines.
- PICOS search strategy employed.
- Included case-control, cohort, experimental studies, and case reports in English.
Main Results:
- 282 abstracts and 114 full articles on post-traumatic osteoarthritis after malleolar fractures were selected.
- Evidence synthesized regarding PTOA development and molecular mechanisms.
Conclusions:
- PTOA involves complex biological, structural, mechanical, and molecular interactions.
- Holistic study of these factors is essential for understanding PTOA progression.
- Targeting single catabolic molecules is unlikely to suffice for altering PTOA progression.
