Thromboelastogram and coagulation function index: relevance for female breast cancer

Area of Science:

• Oncology
• Hematology
• Medical Diagnostics

Background:

• Screening and postoperative intervention for breast tumors are crucial for effective diagnosis and treatment.
• Reliable diagnostic and screening methods are essential for managing breast disease progression.

Purpose of the Study:

• To explore the predictive value of thromboelastogram (TEG), routine platelet (PLT) count, and coagulation function indicators in patients with breast diseases for secondary bleeding disorders.
• To analyze differences in coagulation parameters between benign and malignant breast diseases.

Main Methods:

• 131 patients with breast diseases were selected.
• Thromboelastogram (TEG), routine platelet (PLT) count, and coagulation function indicators were determined.
• Receiver operating curve (ROC) analysis was used to evaluate predictive value.

Main Results:

• Malignant breast disease group showed lower reaction (R) and coagulation (K) times, but higher coagulation angle (α), maximum amplitude (MA), coagulation index (CI), fibrinogen (FIB), and D-dimer (D-D) compared to the benign group.
• MA and FIB values were statistically significant (p < 0.05) between benign and malignant groups.
• ROC analysis indicated significant predictive value for CI and α angle in secondary bleeding disorders.

Conclusions:

• Coagulation tests reveal significant differences in breast cancer patients compared to those with benign breast diseases.
• TEG combined with conventional coagulation indicators shows potential value in predicting secondary bleeding disorders in breast cancer patients.