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Association between glycemia and multi-vessel lesion in participants undergoing coronary angiography: a

Hezeng Dong1, Zhaozheng Liu2, Hao Chen2

  • 1College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China.

Frontiers in Cardiovascular Medicine
|August 1, 2024
PubMed

Insights

Elevated blood glucose levels (glycemia) are linked to more widespread coronary artery disease (multi-vessel lesions). This association is stronger in men, older individuals, and smokers.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Multi-vessel lesions in CAD indicate a more severe disease state.
  • The role of glycemia in the extent of coronary artery disease requires further elucidation.

Purpose of the Study:

  • To investigate the association between glycemia and the presence of multi-vessel lesions in patients undergoing coronary angiography.
  • To determine if glycemia is an independent risk factor for extensive coronary artery disease.

Main Methods:

  • A retrospective analysis of 2,533 patients who underwent coronary angiography was performed.
  • 1,973 patients with coronary artery disease were analyzed for multi-vessel lesions.
  • Univariate and multivariate logistic regression analyses were used to assess the relationship between glycemia and multi-vessel lesions.

Main Results:

  • A significant positive correlation was found between glycemia and the occurrence of coronary multi-vessel lesions (OR 1.04; 95% CI 1.01-1.08; p=0.02).
  • Each unit increase in glycemia was associated with a 4% increased risk of developing multi-vessel lesions (p<0.05).
  • Subgroup analyses indicated that the association was more pronounced in men, patients over 45, and smokers.

Conclusions:

  • Glycemia is significantly associated with the incidence of multi-vessel lesions in patients with coronary artery disease.
  • The findings highlight glycemia as a crucial factor in the severity of coronary artery disease.
  • Risk stratification for multi-vessel lesions should consider glycemia, especially in high-risk subgroups.
Abstract

Keywords:
Asiancoronary angiographydiabetesglycemiamulti-vessel lesion

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