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Testosterone Therapy as an Isolated Risk Factor for Venous Thrombosis: A Case Report.

Kara Bragg¹, Hailey Miller², Ricky Buckshaw²

¹Emergency Medicine, Mayo Clinic, Jacksonville, USA.

|August 1, 2024

Summary

Testosterone replacement therapy (TRT) may increase the risk of venous thromboembolism (VTE). This case study highlights a young male patient with VTE despite low-risk scores, prompting a reevaluation of risk assessment tools.

Keywords:

case report pulmonary embolism rule-out criteria (perc)testosterone venous thrombus embolism wells' criteria

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Published on: June 15, 2011

Area of Science:

Medical research
Clinical case study
Cardiovascular health

Background:

Venous thromboembolism (VTE) is a significant clinical concern diagnosed and treated in emergency departments.
Current VTE risk assessment tools do not incorporate testosterone replacement therapy (TRT) as a risk factor.
TRT is increasingly used in both male and female patients.

Observation:

A young adult male, assessed as low risk for VTE, presented with acute deep vein thrombosis and pulmonary emboli.
The patient was undergoing testosterone replacement therapy at the time of presentation.
Standard VTE scoring tools did not identify this patient as high risk.

Findings:

This case demonstrates a potential link between TRT and the occurrence of VTE, even in low-risk individuals.
Existing VTE risk stratification tools may be insufficient in patients receiving TRT.
Recent research suggests an association between TRT and increased VTE risk, though reports are conflicting.

Implications:

Clinical decision tools for VTE risk assessment should be updated to include TRT.
Further research is warranted to establish a definitive correlation between TRT and VTE.
Healthcare providers should consider TRT when evaluating VTE risk in patients.