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Related Experiment Video

Updated: Jun 18, 2025

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Tailored Bioactive Glass Coating: Navigating Devitrification Toward a Superior Implant Performance.

Anustup Chakraborty1,2, Subhadip Bodhak2,3, Indrajit Tah1

  • 1Specialty Glass Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata 700032, India.

ACS Biomaterials Science & Engineering
|August 1, 2024
PubMed
Summary

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This summary is machine-generated.

Researchers developed novel bioactive glass coatings for metallic implants by substituting sodium oxide with calcium oxide. These amorphous coatings exhibit enhanced bioactivity, improved thermal properties, and excellent cytocompatibility for superior clinical applications.

Area of Science:

  • Biomaterials Engineering
  • Materials Science
  • Biomedical Engineering

Background:

  • Developing adherent, amorphous, bioactive glass coatings for metallic implants is challenging.
  • Traditional bioactive glasses suffer from crystallization and thermal expansion mismatch with implants.

Purpose of the Study:

  • To overcome limitations of traditional bioactive glasses.
  • To develop novel amorphous, bioactive glass coatings with enhanced properties for metallic implants.

Main Methods:

  • Systematic Na2O substitution with CaO in borosilicate glasses.
  • Structural analysis using molecular dynamics (MD) simulations, Raman spectroscopy, and Nuclear Magnetic Resonance (NMR).
  • Optimization of a consolidation process based on crystallization kinetics and viscosity-temperature data.
Keywords:
antibacterial actionbioactive glass coatingcrystallization kineticscytocompatibilitymetallic implants

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Last Updated: Jun 18, 2025

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Main Results:

  • Tailored borosilicate glass composition with improved thermal stability and reduced thermal expansion.
  • Optimal bioactivity demonstrated by *in vitro* bone-like apatite formation within 3 days.
  • Amorphous, crack-free coatings on Ti-6Al-4V substrates with a matched coefficient of thermal expansion.

Conclusions:

  • The novel glass coating exhibits excellent cytocompatibility and antibacterial properties.
  • This approach offers a promising alternative to existing technologies for biomedical implants.
  • The developed coatings show superior clinical potential for metallic implants.