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Updated: Jul 14, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Clear cell renal cancer metastasis - A case of delayed diagnosis
Sónia Barros1, Luís Miguel Relvas2, Isabel Malta Carvalho3
1Gastroenterology , Unidade de Saúde Local do Algarve - Unidade de Faro, Portugal .
Abstract:
Renal cell carcinoma represents about 90% of all primary renal neoplasms. Clear cell renal cell carcinoma is the most common histological type, characterized by an aggressive clinical course due to its tendency to metastasize. Metastases are typically diagnosed on average 5 years after oncological surgery. Compared to metastasis to other organs, pancreatic metastases are rare. We present a case of clear cell renal carcinoma metastasis to the pancreas and liver, diagnosed 23 years after nephrectomy during the investigation of portal hypertension findings. Evaluating the late recurrence of clear cell renal carcinoma is crucial. There are no guidelines regarding the appropriate follow-up period after nephrectomy, and prospective studies may be useful in the future.
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