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Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
High expression of EBP is an adverse prognostic factor for de novo acute myeloid leukemia

High expression of EBP is an adverse prognostic factor for de novo acute myeloid leukemia

Jiaying Lian ^1,2, Haihui Zhuang ^1,2, Fenglin Li ^1,2, Renzhi Pei ^1,2, Dong Chen ^1,2, Peipei Ye ^1,2, Shuangyue Li ^1,2, Tiantian Wang ^1,2, Junjie Cao ^1,2, Jiaojiao Yuan ^1,2, Zhuruohan Yu ^1,2, Ying Lu ^1,2

Jiaying Lian ^1,2, Haihui Zhuang ^1,2, Fenglin Li ^1,2

¹Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, People's Republic of China.
²Institute of Hematology, Ningbo University, Ningbo, People's Republic of China.

⁰Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, People's Republic of China.

Hematology (amsterdam, Netherlands) +

|

August 1, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

High emopamil-binding protein gene (EBP) expression in acute myeloid leukemia (AML) patients indicates a poor prognosis. However, hematopoietic stem cell transplantation may improve survival outcomes for these patients.

Area Of Science

Oncology
Molecular Biology
Genetics

Background

Acute myeloid leukemia (AML) is a complex cancer requiring reliable prognostic markers.
Emopamil-binding protein gene (EBP) inhibition can induce cancer cell death by depleting sterols.
No prior studies comprehensively examined EBP expression in AML tumors.

Purpose Of The Study

To investigate the prognostic value of emopamil-binding protein gene (EBP) expression in acute myeloid leukemia (AML).
To assess the impact of EBP levels on patient survival and clinical characteristics.
To evaluate the effect of EBP expression on treatment outcomes, specifically hematopoietic stem cell transplantation.

Main Methods

Survival analyses were conducted using The Cancer Genome Atlas (TCGA) dataset.
Emopamil-binding protein gene (EBP) expression was quantified via real-time qPCR in 120 AML patients.
Clinical data from AML patients were analyzed to assess EBP's prognostic value.

Main Results

High EBP expression correlated with worse overall survival (OS) and event-free survival (EFS) in both TCGA and clinical cohorts.
Elevated EBP levels were associated with higher white blood cell (WBC) counts.
Multivariate analysis confirmed high EBP expression as an independent adverse prognostic factor for OS and EFS in AML.
Hematopoietic stem cell transplantation improved survival in high-EBP expressing patients, including those with intermediate-risk AML.

Conclusions

High emopamil-binding protein gene (EBP) expression is an adverse prognostic marker in acute myeloid leukemia (AML).
Hematopoietic stem cell transplantation can mitigate the negative prognostic impact of high EBP expression in AML patients.
EBP may serve as a therapeutic target or a marker for treatment selection in AML.

Keywords:

AML EBP consolidation prognosis transplantation

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