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Related Concept Videos

Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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Suicide by Ethyl Methacrylate Ingestion.

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This case report details a unique suicide method involving the ingestion of ethyl methacrylate and acrylic powder, commonly used for artificial nails. Autopsy revealed severe gastrointestinal damage, confirming this as the cause of death.

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Area of Science:

  • Toxicology
  • Forensic Pathology
  • Occupational Health

Background:

  • Acrylic nail application involves mixing ethyl methacrylate and acrylic powder.
  • Ingestion of these chemicals is not previously documented in medical literature.
  • The decedent was a nail technician, suggesting occupational exposure or intentional ingestion.

Purpose of the Study:

  • To document a novel method of suicide by ingesting acrylic nail chemicals.
  • To describe the unique autopsy findings associated with this type of poisoning.
  • To raise awareness of potential chemical hazards in occupational settings like nail salons.

Main Methods:

  • Case report analysis of a deceased individual.
  • Review of scene investigation findings.
  • Autopsy examination including gross pathology and toxicology.

Main Results:

  • Decedent found deceased with a partially empty bottle of ethyl methacrylate.
  • Autopsy revealed significant gastrointestinal tract damage, including esophageal discoloration.
  • Stomach contents showed a hardened, molded acrylic nail compound.
  • Cause of death attributed to complications from ingesting ethyl methacrylate and acrylic powder.

Conclusions:

  • Ingestion of ethyl methacrylate and acrylic powder represents an unusual and fatal method of suicide.
  • Autopsy findings included characteristic chemical burns and a solidified mass in the gastrointestinal tract.
  • This case highlights the potential for severe toxicity from commonly used industrial chemicals.