Related Experiment Video

Updated: Jun 18, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.2K

The potential role of circular RNAs in regulating p53 in different types of cancers

Elham Farhadi1, Mohammadreza Khomeijani-Farahani2, Rambod Nikbakhsh3

  • 1Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|August 1, 2024
PubMed

Insights

Circular RNAs (circRNAs) regulate the tumor suppressor p53. Targeting these circRNAs offers potential new cancer therapies by modulating p53 activity and stability.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The p53 tumor suppressor is critical for cellular regulation and its inactivation drives cancer development.
  • Circular RNAs (circRNAs) are non-coding RNAs influencing gene expression post-transcriptionally.
  • Understanding the interplay between p53 and circRNAs is vital for cancer research.

Purpose of the Study:

  • To review circRNAs that regulate p53 expression, function, and stability.
  • To explore the interactions between p53 and circRNAs.
  • To highlight the therapeutic potential of targeting circRNAs in cancer.

Main Methods:

  • Literature review of studies on circRNAs and p53.
  • Analysis of molecular mechanisms of circRNA-p53 interactions.
  • Synthesis of current knowledge on circRNA regulation of p53.

Main Results:

  • Identified various circRNAs that modulate p53 levels and activity.
  • Detailed mechanisms by which circRNAs affect p53 stability and function.
  • Established a network illustrating circRNA influence on p53 pathways.

Conclusions:

  • circRNAs significantly impact p53 regulation in cancer.
  • Targeting specific circRNAs could offer novel therapeutic strategies for p53-related cancers.
  • Further clinical investigation into circRNA-based therapies is warranted.
Keywords:
CancerCircular RNAsLong non-coding RNAsMDM2P53Tumor suppression

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.5K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.3K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
6.8K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K