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Timing of pertussis vaccination during pregnancy: Evidence and implementation - A systematic review

Louise De Weerdt1, Sereina A Herzog2, Pierre Van Damme1

  • 1Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.

Vaccine
|August 1, 2024
PubMed

Insights

Vaccinating pregnant individuals against pertussis (whooping cough) early in the third trimester offers optimal infant protection. Later vaccinations may reduce vaccine effectiveness, highlighting the need for consistent global recommendations.

Area of Science:

  • Immunology
  • Public Health
  • Vaccinology

Background:

  • Maternal pertussis vaccination is increasingly adopted globally to protect newborns during their vulnerable first weeks.
  • Optimal timing for antenatal pertussis immunization remains a subject of ongoing discussion and research.

Approach:

  • A systematic review of 45 publications was conducted, analyzing safety, immunogenicity, and effectiveness data related to the timing of pertussis vaccination during pregnancy.
  • Global governmental recommendations for antenatal pertussis vaccination timing were also mapped.

Key Points:

  • No increased safety concerns were identified with different vaccination timings in pregnancy.
  • Early third-trimester vaccination appears to optimize infant immunogenicity at birth.
  • Late third-trimester vaccination may be associated with reduced vaccine effectiveness compared to earlier administration.

Conclusions:

  • The timing of pertussis vaccination during pregnancy significantly influences infant immunogenicity and vaccine effectiveness.
  • Early third-trimester vaccination is suggested for maximal infant protection at birth.
  • Divergent national recommendations worldwide reflect the inconsistent and limited data available on optimal vaccination timing.
Abstract

Keywords:
PertussisPregnancyRecommendationTimingVaccination

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