Generalizable diagnosis of chest radiographs through attention-guided decomposition of images utilizing...

Chest X-ray (CXR) is one of the most commonly performed imaging tests worldwide. Due to its wide usage, there is a growing need for automated and generalizable methods to accurately diagnose these images. Traditional methods for chest X-ray analysis often struggle with generalization across diverse datasets due to variations in imaging protocols, patient demographics, and the presence of overlapping anatomical structures. Therefore, there is a significant demand for advanced diagnostic tools that can consistently identify abnormalities across different patient populations and imaging settings. We propose a method that can provide a generalizable diagnosis of chest X-ray.

Our method utilizes an attention-guided decomposer network (ADSC) to extract disease maps from chest X-ray images. The ADSC employs one encoder and multiple decoders, incorporating a novel self-consistency loss to ensure consistent functionality across its modules. The attention-guided encoder captures salient features of abnormalities, while three distinct decoders generate a normal synthesized image, a disease map, and a reconstructed input image, respectively. A discriminator differentiates the real and the synthesized normal chest X-rays, enhancing the quality of generated images. The disease map along with the original chest X-ray image are fed to a DenseNet-121 classifier modified for multi-class classification of the input X-ray.

Experimental results on multiple publicly available datasets demonstrate the effectiveness of our approach. For multi-class classification, we achieve up to a 3% improvement in AUROC score for certain abnormalities compared to the existing methods. For binary classification (normal versus abnormal), our method surpasses existing approaches across various datasets. In terms of generalizability, we train our model on one dataset and tested it on multiple datasets. The standard deviation of AUROC scores for different test datasets is calculated to measure the variability of performance across datasets. Our model exhibits superior generalization across datasets from diverse sources.

Our model shows promising results for the generalizable diagnosis of chest X-rays. The impacts of using the attention mechanism and the self-consistency loss in our method are evident from the results. In the future, we plan to incorporate Explainable AI techniques to provide explanations for model decisions. Additionally, we aim to design data augmentation techniques to reduce class imbalance in our model.