Related Experiment Video
Updated: Jun 18, 2025
12:18
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
10.0K
Securing skin grafts: A network meta-analysis.
Konstantinos Seretis1, Nikolaos Bounas1
1Department of Plastic Surgery, Medical School, University of Ioannina, Ioannina, Greece.
Summary
Negative pressure wound therapy (NPWT) significantly improves skin graft take rates compared to other methods. Tie-over bolster (TOB) showed the worst results, though NPWT
Area of Science:
- Plastic Surgery
- Wound Healing
- Regenerative Medicine
Background:
- Skin grafting is a common plastic surgery procedure.
- Optimal graft fixation guidelines are lacking.
- Evidence on graft securing methods needs consolidation.
Purpose of the Study:
- To compare various skin graft fixation methods.
- To identify the most effective approach for clinical practice.
- To consolidate existing evidence through network meta-analysis.
Main Methods:
- Network meta-analysis (NMA) of 27 studies.
- Inclusion of 1937 adult patients.
- Data search from inception to October 2023.
Main Results:
- Negative pressure wound therapy (NPWT) significantly improved graft take percentages.
- Tie-over bolster (TOB) demonstrated the worst graft take rates.
- Fibrin glue (FIB) and TOB reduced hematoma and seroma rates.
Conclusions:
- NPWT is the most effective method for skin graft adherence.
- Cost-effectiveness of NPWT requires further investigation.
- FIB and TOB can reduce hematoma/seroma in high-risk patients.
