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Updated: Jun 18, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Sign of Leser-Trélat Associated with Kaposi Sar-coma in an Immunocompetent Man
Hershel E Dobkin1, Juan P Estrada2, Allen Sapadin2
1Department of Dermatology, Hackensack University Medical Center, Hackensack, NJ; hersheldobkinpublic@gmail.com.
Abstract:
A 68-year-old Latino man presented at our clinic with asymptomatic, indurated red nodules and macules of 2-month duration on the left arm, forearm, and palm (Figure 1). Performed punch biopsy presented characteristic -features of Kaposi sarcoma (KS). Immunohistochemistry was positive for human herpesvirus 8 (HHV8), a highly correlated viral marker, confirming the diagnosis of KS (Figure 2). He was referred to oncology for further management, where he was found to be fully immunocompetent with a negative assessment of human immunodefi-ciency virus (HIV). Computed tomography (CT) performed of his chest and abdomen revealed no involvement of internal organs.
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