Related Experiment Video
Updated: Jun 18, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
The Mystery of an Inflamed "Soul Patch"
Kayla Brockmeyer1, Patrick McMahon2
1Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia PA; kmb047@students.jefferson.edu.
A man with persistent facial dermatitis was initially misdiagnosed with herpes simplex. Fungal infection by Trichophyton mentagrophytes was identified and successfully treated with oral terbinafine and ketoconazole.
Area of Science:
- Dermatology
- Mycology
- Infectious Diseases
Background:
- Facial dermatitis can present with varied etiologies, sometimes mimicking other conditions.
- Accurate diagnosis is crucial for effective treatment of skin infections.
Observation:
- A 20-year-old male presented with a month of scalp and 'soul patch' dermatitis.
- Initial treatments for presumed herpes simplex virus infection were ineffective.
- Physical exam revealed crusted plaques, erythema, edema, scaling, and hair loss, with cervical lymphadenopathy.
Findings:
- Fungal culture isolated *Trichophyton mentagrophytes*.
- Bacterial culture yielded no growth.
- The patient owned a dog, a potential source for zoophilic dermatophyte infection.
Implications:
- This case highlights the importance of considering fungal infections in refractory dermatitis.
- Prompt identification and targeted antifungal therapy, including terbinafine and ketoconazole, led to complete resolution.
- Dermatologists should consider dermatophytosis in the differential diagnosis of facial and scalp lesions, especially with exposure to animals.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Inflammation
Accessory Structures of the Skin: Sebaceous Glands
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Accessory Structures of the Skin: Hair and Hair Follicles
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.

