Related Experiment Video
Updated: Jun 18, 2025
08:13
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
68.2K
Association between triglyceride-glucose index and gallstones: a cross-sectional study
Hongliang Li1, Congfeng Zhang2
1Department of General Surgery, Dandong Central Hospital, Dandong, China.
Scientific Reports
|August 1, 2024
Summary
The triglyceride-glucose (TyG) index is linked to a higher risk of gallstones. This finding suggests the TyG index can predict gallstone development, particularly in specific demographic groups.
Area of Science:
- Metabolic Syndrome Research
- Gastroenterology
- Epidemiology
Background:
- Gallstones are a common gastrointestinal condition.
- The triglyceride-glucose (TyG) index is emerging as a marker for metabolic dysfunction.
- Understanding predictors for gallstone formation is crucial for public health.
Purpose of the Study:
- To investigate the association between the triglyceride-glucose (TyG) index and the prevalence of gallstones.
- To identify subgroups at higher risk for gallstones based on TyG index levels.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2017-2020.
- Included 3870 participants aged over 20 years.
- Employed logistic regression, subgroup analysis, and smooth curve fitting to analyze the relationship.
Main Results:
- A 10.4% prevalence of gallstones was observed in the study population.
- Each unit increase in the TyG index was associated with a 41% increased risk of gallstones (OR 1.41).
- A positive correlation was confirmed by smooth curve fitting and observed in subgroups including women, those <50 years, and individuals with BMI >25.
Conclusions:
- The triglyceride-glucose (TyG) index is positively correlated with gallstone risk.
- The TyG index serves as a potential predictive marker for gallstone development.
- Targeted interventions may be beneficial for individuals with elevated TyG index levels.
Keywords:
Cross-sectional studyGallstonesInsulin resistance (IR)NHANESTriglyceride-glucose (TyG) indexMore Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
214
09:44Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
2.9K
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
143
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
143
01:30Acute Pancreatitis II: Clinical Manifestations and Management
118
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
118
01:29Cholesterol: Significance and Regulation
524
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
524
01:27Glucose Transporters
22.6K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.6K
01:24Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
01:26Glucose Absorption Into the Small Intestine
31.5K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.5K