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Updated: Jun 18, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
Published on: November 11, 2020
A model study on the effect of human's height variability in particle deposition and retained dose in the respiratory
Eleftheria Chalvatzaki1, Mihalis Lazaridis2
1School of Chemical and Environmental Engineering, Technical University of Crete, 73100, Chania, Crete, Greece.
Abstract:
The objective of the current study was to investigate the impact of human's height variability to the deposition percentage, the deposited and the retained dose of particulate matter in the respiratory tract. In addition, the dose to the oesophagus, blood and lymph nodes was evaluated after particle clearance. A methodology which correlates anatomical and physiological parameters with height was adopted into an existing particle dosimetry model (Exposure Dose Model 2, ExDoM2). Model results showed that deposition of particles with aerodynamic diameter (dae) ranging from 0.001 to 10 μm depends on the competition between anatomical/physiological parameters, with the maximum effect induced from height variability to be observed for particles in the size range of 0.30 μm
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