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[Gender medicine in lung diseases]
Laura V Klotz1,2, Henrike Deissner3, Florian Eichhorn3
1Klinik für Thoraxchirurgie, Thoraxklinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland. Laura.Klotz@med.uni-heidelberg.de.
Chirurgie (Heidelberg, Germany)
|August 1, 2024
Summary
Gender influences lung disease diagnosis and treatment. Women with lung cancer show better prognoses and survival rates, while experiencing more immune-related adverse events during treatment.
Area of Science:
- Pulmonology and Oncology
- Gender Medicine
Context:
- Lung diseases exhibit significant gender-specific variations in etiology, treatment, and recurrence.
- Catamenial pneumothorax necessitates a multidisciplinary approach involving gynecology for reduced recurrence.
- Lung cancer incidence is equalizing between genders, highlighting the importance of gender-specific factors.
Purpose:
- To explore gender-specific differences in the diagnosis and treatment of lung diseases.
- To underscore the relevance of gender in lung cancer prognosis and treatment outcomes.
- To examine how gender impacts tolerability and survival in lung cancer clinical trials.
Summary:
- Gender plays a crucial role in the presentation and management of lung diseases like pneumothorax and lung cancer.
- Female patients with lung cancer demonstrate a more favorable prognosis, higher rates of driver mutations, and improved event-free survival.
- Despite better outcomes, women in lung cancer trials report a higher incidence of immune-mediated adverse events.
Impact:
- Highlights the need for personalized treatment strategies considering gender in lung disease management.
- Informs clinical trial design and interpretation by accounting for gender-based differences in treatment response and adverse events.
- Emphasizes the importance of interdisciplinary collaboration, particularly in conditions like catamenial pneumothorax.
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