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Updated: Jun 18, 2025
14:27
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
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The interaction between cannabinoids and long-term synaptic plasticity: A survey on memory formation and underlying
Maryam Azarfarin1,2,3, Tahereh Ghadiri1, Masoomeh Dadkhah3
1Department of Neuroscience,Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Biochemistry and Function
|August 2, 2024
Summary
Cannabis use impacts synaptic plasticity and memory, with effects varying by dosage and consumption method. Understanding these interactions is crucial due to rising cannabis use and potential long-term cognitive health challenges.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), is vital for memory and cognitive functions.
- Cannabis (marijuana) contains exocannabinoids that can impair attention and working memory.
Purpose of the Study:
- To review the complex effects of exogenous cannabinoids on synaptic plasticity, particularly LTP.
- To examine the interaction of cannabinoids with cannabinoid receptors (CBRs) and other neural pathways.
Main Methods:
- Literature review of studies on cannabinoids, synaptic plasticity, and memory.
- Analysis of research on exogenous cannabinoids, CBRs agonists/antagonents, and endocannabinoids.
Main Results:
- Evidence on cannabinoid effects on LTP and memory is contradictory.
- Cannabinoid impact is multifactorial, depending on dosage, timing, formula, and route of consumption.
- Cannabinoids interact with CBRs and other cerebral networks, influencing synaptic plasticity.
Conclusions:
- Cannabis use presents a potential global health challenge due to its impact on learning and memory.
- Further research is needed to clarify the precise mechanisms and long-term consequences of cannabinoid use on cognitive functions.
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