Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computational Framework for Modeling Effects of Brain Collateral Circulation.

International journal for numerical methods in biomedical engineering·2025
Same author

Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall.

International journal for numerical methods in biomedical engineering·2025
Same author

Modeling Hemodynamic Effects of the Closure Procedure of Carotid Artery Endarterectomy.

International journal for numerical methods in biomedical engineering·2025
Same author

Influence of Vessel Geometry, Flow Conditions, and Thrombin Concentration on Fibrin Accumulation and Cerebral Aneurysm Occlusion After Flow Diversion.

International journal for numerical methods in biomedical engineering·2024
Same author

Modeling Fibrin Accumulation on Flow-Diverting Devices for Intracranial Aneurysms.

International journal for numerical methods in biomedical engineering·2024
Same author

Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions.

International journal for numerical methods in biomedical engineering·2024

Related Experiment Video

Updated: Jul 11, 2026

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
12:15

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

23.1K

Flow reduction due to arterial catheterization during stroke treatment - A computational study using a distributed

Aseem Pradhan1, Fernando Mut1, Medhini Sosale1

  • 1Bioengineering Department, George Mason University, Fairfax, Virginia, USA.

International Journal for Numerical Methods in Biomedical Engineering
|August 2, 2024
PubMed
Summary

Catheterization during stroke treatment may reduce blood flow by up to 45% in affected brain regions. This risk is higher in patients with poor collateral circulation, impacting treatment effectiveness.

Keywords:
catheter insertioncollateral circulationcomputational hemodynamicsdistributed compartment modelendovascular interventionsstroke treatment

More Related Videos

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
07:26

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

7.1K
Author Spotlight: A Novel Approach to Cerebral Ischemia Modeling – Enhancing Reperfusion and Simplifying Procedure
04:18

Author Spotlight: A Novel Approach to Cerebral Ischemia Modeling – Enhancing Reperfusion and Simplifying Procedure

Published on: May 31, 2024

1.0K

Related Experiment Videos

Last Updated: Jul 11, 2026

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
12:15

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

23.1K
Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
07:26

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

7.1K
Author Spotlight: A Novel Approach to Cerebral Ischemia Modeling – Enhancing Reperfusion and Simplifying Procedure
04:18

Author Spotlight: A Novel Approach to Cerebral Ischemia Modeling – Enhancing Reperfusion and Simplifying Procedure

Published on: May 31, 2024

1.0K

Area of Science:

  • Biomedical Engineering
  • Neurology
  • Medical Imaging

Background:

  • Cerebral vasculature and collateral networks are crucial for stroke treatment efficacy.
  • Ischemic stroke treatments often involve catheterization, but its impact on blood flow has been understudied.
  • Collateral pathways, including the Circle of Willis and leptomeningeal arteries, are vital for maintaining brain perfusion during primary vessel obstruction.

Purpose of the Study:

  • To investigate the potential for reduced blood flow in the brain due to catheterization during ischemic stroke treatment.
  • To quantify the impact of catheter insertion on cerebral blood flow in various collateralization scenarios.
  • To validate a novel 0D model for simulating blood flow alterations during stroke interventions.

Main Methods:

  • Developed and validated a 0D lumped parameter model for catheterized blood vessels.
  • Validated the 0D model against experimental and 1D model benchmarks.
  • Compared 0D model results with 3D simulations of off-center catheter trajectories.
  • Simulated blood flow in realistic cerebral arterial networks with varying collateralization during M1 middle cerebral artery occlusion.

Main Results:

  • The 0D model accurately represented catheter effects, with minimal differences compared to 3D simulations.
  • Simulations revealed maximum blood flow reductions of up to 45% in the affected brain region.
  • The degree of flow reduction was significantly influenced by the patient's collateralization status.

Conclusions:

  • Catheterization, a standard stroke treatment, can significantly reduce blood flow to the ischemic brain.
  • Patients with insufficient collateral blood supply are at a higher risk of experiencing detrimental flow reductions during catheter-based interventions.
  • These findings highlight the need to consider collateral status when assessing the risks and benefits of catheterization in stroke treatment.