Related Experiment Video

Updated: Jun 18, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

112

Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases

Song Mao1

  • 1Department of Pediatrics, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Renal Failure
|August 2, 2024
PubMed
Abstract

Insights

Uncoupling protein 2 (UCP2) plays a key role in kidney disease development. Maintaining UCP2 homeostasis is crucial for kidney health, with its specific functions varying across different renal injuries.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Uncoupling protein 2 (UCP2) is implicated in the pathogenesis and progression of kidney diseases.
  • Numerous signaling pathways and factors influence UCP2 expression and function.

Purpose of the Study:

  • To investigate the precise role of UCP2 in kidney diseases.
  • To elucidate the signaling pathways regulating UCP2 in renal contexts.

Main Methods:

  • A comprehensive review and summarization of existing evidence.
  • Analysis of UCP2 interactions and signaling pathways in kidney disease models.

Main Results:

  • UCP2 interacts with proteins like 14.3.3, iPLA2γ, NMDAR, glucokinase, and PPARγ.
  • UCP2 signaling pathways involving NMDAR and PPARγ were identified.
  • UCP2 inhibits reactive oxygen species (ROS) production, inflammation, and apoptosis, offering protection against acute kidney injury (AKI).
  • UCP2 reduces ATP production and insulin secretion, potentially mitigating chronic kidney damage like diabetic nephropathy and fibrosis.

Conclusions:

  • Maintaining UCP2 homeostasis is beneficial for overall kidney health.
  • UCP2 exhibits context-dependent roles, potentially exerting different effects in various types of renal injury.
Keywords:
Uncoupling protein 2homeostasiskidney diseasesreactive oxygen speciessignaling pathways

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