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Carnosine and Retinol Synergistically Inhibit UVB-Induced PGE2 Synthesis in Human Keratinocytes through the

In Guk Park1, Sun Hee Jin1, Seungchan An1

  • 1Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Biomolecules & Therapeutics
|August 2, 2024
PubMed

Insights

This study shows that combining carnosine and retinol boosts hyaluronic acid (HA) production and reduces inflammation, effectively improving skin aging signs caused by UV exposure.

Area of Science:

  • Dermatology
  • Biochemistry
  • Molecular Biology

Background:

  • Skin aging involves intrinsic and extrinsic factors, causing wrinkles and dryness.
  • Ultraviolet (UV) radiation degrades skin hyaluronic acid (HA), leading to inflammation.

Purpose of the Study:

  • To investigate the synergistic effect of carnosine and retinol (ROL) on HA production and inflammation in skin cells.
  • To determine if combined carnosine and ROL can mitigate UV-induced skin aging.

Main Methods:

  • Utilized normal human epidermal keratinocytes (NHEKs).
  • Assessed the impact of carnosine and ROL on hyaluronan synthase 2 (HAS2) gene transcription.
  • Measured prostaglandin E2 (PGE2) synthesis following UVB irradiation.

Main Results:

  • Carnosine and ROL synergistically increased HA production by upregulating HAS2 gene transcription.
  • Combined treatment significantly reduced UVB-induced PGE2 synthesis in NHEKs.
  • A correlation was found between increased HA synthesis and inhibited PGE2 production.

Conclusions:

  • Combined carnosine and ROL treatment enhances HA synthesis and reduces inflammation.
  • This combination therapy shows potential for improving skin aging phenotypes induced by UVB radiation.
Keywords:
CarnosineHyaluronic acidInflammationPGERetinolSkin aging

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