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Iron: The Secret Ingredient Breaking PARPi Resistance

Hamed Alborzinia1,2, José Pedro Friedmann Angeli3

  • 1Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.

Cancer Discovery
|August 2, 2024
PubMed
Summary

Poly (ADP-ribose) polymerase inhibitors (PARPi) show limited efficacy in some cancers. This study reveals PARPi increase ferroptosis sensitivity, offering a new therapeutic strategy to improve treatment response in BRCA1/2 mutated cancers.

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