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Updated: Jun 18, 2025

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The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics

Jai Prakash1, Yuval Shaked2

  • 1Engineered Therapeutics Group, Department of Advanced Organ Bioengineering and Therapeutics, Technical Medical Centre, University of Twente, Enschede, the Netherlands.

Cancer Discovery
|August 2, 2024
PubMed

Insights

The extracellular matrix (ECM) protects tumors but also drives resistance. Cancer therapies remodel the ECM, paradoxically promoting tumor progression and treatment failure, highlighting challenges in targeting the ECM.

Area of Science:

  • Oncology
  • Cancer Biology
  • Biomedical Engineering

Background:

  • The extracellular matrix (ECM) is a key component of solid tumors, influencing tumor progression and metastasis.
  • The ECM acts as a physical barrier, potentially protecting tumors from anticancer agents.
  • Emerging evidence indicates that cancer therapies can induce ECM remodeling, leading to treatment resistance.

Purpose of the Study:

  • To review the critical interplay between the extracellular matrix and cancer therapeutics.
  • To discuss how the ECM influences treatment outcomes in cancer.
  • To explore the impact of cancer therapies on ECM remodeling and the challenges in targeting the ECM.

Main Methods:

  • Literature review of existing studies on ECM and cancer therapeutics.
  • Analysis of the dual role of ECM in tumor progression and therapy resistance.
  • Discussion of the mechanisms by which cancer therapies induce ECM remodeling.

Main Results:

  • The ECM's biomechanical properties can impede drug delivery and efficacy.
  • Therapy-induced ECM remodeling is a significant factor in acquired resistance and tumor recurrence.
  • Targeting the ECM presents complex challenges due to its multifaceted roles.

Conclusions:

  • The relationship between ECM and cancer therapeutics is intricate, offering new insights into tumor biology.
  • Understanding ECM remodeling is crucial for developing effective cancer treatment strategies.
  • Further research is needed to overcome challenges in targeting the ECM for improved therapeutic outcomes.

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