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Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

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Related Experiment Video

Updated: Jun 18, 2025

Study of Cell Migration in Microfabricated Channels

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

Decoding physical principles of cell migration under controlled environment using microfluidics.

Young Joon Suh¹, Alan T Li¹, Mrinal Pandey¹

¹Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.

Biophysics Reviews

|August 2, 2024

Summary

This summary is machine-generated.

Cells utilize physical principles for sensing and migration, mimicking advanced biological functions. Microfluidic platforms enable studying these cellular behaviors in controlled environments.

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Area of Science:

Cell Biology
Biophysics
Microfluidics

Background:

Living cells exhibit complex behaviors, such as pathogen detection and migration, surpassing current micro/nano-robot capabilities.
Evolution has refined cellular functions, suggesting underlying physical principles govern sensing, adaptation, and movement.
Microfluidics offers a powerful tool to study cell migration by recreating precise cellular environments and enabling theoretical modeling.

Purpose of the Study:

To explore the physical principles governing cellular sensing, adaptation, and migration.
To review the development of microfluidic platforms for studying cell migration in 3D.
To summarize principles of cellular response to chemical gradients and biophysical cues.

Main Methods:

Development of microfluidic platforms to create controlled biophysical (mechanical stress) and biochemical (nutrients, cytokines) environments.
Utilizing microfluidic systems to study single-cell dynamics in 3D.
Analyzing cellular responses to chemical gradients and biophysical cues.

Main Results:

Microfluidic systems have revealed basic principles of how cells (bacteria, algal, mammalian) respond to chemical gradients.
Studies under biophysical cues have provided novel biological insights into cell migration.
Demonstrated the utility of microfluidics for quantitative studies of cell function.

Conclusions:

Cells operate based on fundamental physical principles for sensing and migration.
Microfluidics is crucial for dissecting cellular behaviors in well-defined environments.
Further quantitative research in controlled biophysical settings is needed to fully understand cell functions.