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Updated: Jun 18, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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L2086F Mutant ROS1-Rearranged NSCLC Resistant to Repotrectinib Responds to Cabozantinib: A Case Report

Urs Weber1, Kurtis D Davies2, D Ross Camidge1

  • 1Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

JTO Clinical and Research Reports
|August 2, 2024
PubMed

Insights

Repotrectinib shows promise for ROS1-rearranged NSCLC, but resistance can emerge. Cabozantinib offers a subsequent treatment option for patients with specific resistance mutations like L2086F.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Repotrectinib is a novel ROS1 tyrosine kinase inhibitor (TKI) approved for ROS1-rearranged NSCLC.
  • The G2032R mutation is a common resistance mechanism to earlier ROS1 TKIs.
  • Emerging resistance mutations necessitate the exploration of alternative treatment strategies.
Keywords:
CabozantinibCase reportL2086FROS1Repotrectinib

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