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Role of circular RNAs in preeclampsia (Review)

Hengxue Jiang1,2, Tao Meng1, Ziwei Li1

  • 1Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Experimental and Therapeutic Medicine
|August 2, 2024
PubMed

Insights

Circular RNAs (circRNAs) show potential in understanding and diagnosing preeclampsia (PE), a pregnancy hypertension disorder. Research highlights their role in PE pathogenesis, offering new prevention and treatment strategies.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Genetics

Background:

  • Preeclampsia (PE) is a significant hypertensive disorder of pregnancy affecting 3-8% of pregnancies globally.
  • Effective prevention, diagnosis, and treatment of PE remain critical challenges in obstetrics.
  • Circular RNAs (circRNAs) are increasingly recognized for their involvement in the pathogenesis of various diseases, including PE.

Purpose of the Study:

  • To review current research on circRNAs in preeclampsia.
  • To elucidate the expression patterns and functional mechanisms of circRNAs in PE development.
  • To explore the potential of circRNAs as diagnostic biomarkers for PE.

Main Methods:

  • Literature review of studies investigating circRNAs and preeclampsia.
  • Analysis of reported circRNA expression profiles in PE.
  • Summary of functional studies on circRNAs implicated in PE pathogenesis.

Main Results:

  • Evidence suggests specific circRNAs are differentially expressed in preeclampsia.
  • CircRNAs influence PE development through various molecular mechanisms.
  • CircRNAs demonstrate potential as non-invasive biomarkers for PE diagnosis.

Conclusions:

  • CircRNAs represent a promising area for understanding preeclampsia.
  • Further research into circRNAs may lead to novel diagnostic and therapeutic strategies for PE.
  • Investigating circRNAs could significantly advance obstetric care for hypertensive disorders of pregnancy.

Keywords:
circular RNAmicroRNApreeclampsiatrophoblast

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