Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic Proximity Engineering of Valley Pseudospins in a Twisted WSe<sub>2</sub> Moiré Superlattices.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Tunable Proximity Valley Splitting Via Interfacial Exchange Pinning in WSe<sub>2</sub>-CrBr<sub>3</sub>-CrPS<sub>4</sub> Heterostructures.

Nano letters·2026
Same author

Twist-Angle-Controlled Built-In Field Reversal Enables Programmable Self-Powered Photodetection in Low-Symmetry Heterostructures.

Nano letters·2026
Same author

Interfacial Magnetic Order Controls Valley Polarization in WS<sub>2</sub>/Fe<sub>3</sub>GaTe<sub>2</sub> Heterostructures.

The journal of physical chemistry letters·2026
Same author

High-performance self-powered broadband photodetector based on a PtS<sub>2</sub>/MoSe<sub>2</sub> vertical heterostructure.

Optics letters·2026
Same author

Cued unpredictable intermittent access exacerbates loss of control over ethanol drinking.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 18, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

543

Modelling alcohol consumption in rodents using two-bottle choice home cage drinking and optional lickometry-based

Shikun Hou1, Nathaly M Arce Soto1, Elizabeth J Glover1

  • 1Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.

Biorxiv : the Preprint Server for Biology
|August 2, 2024
PubMed
Summary

Researchers can now study ethanol consumption in rats with high-resolution lickometer systems. This adaptation of the LIQ HD system allows detailed analysis of drinking patterns and intake levels in parallel.

Keywords:
addictionalcohol use disorderdrinking patternslickometeropen behavior

More Related Videos

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

7.9K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

884

Related Experiment Videos

Last Updated: Jun 18, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

543
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

7.9K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

884

Area of Science:

  • Neuroscience
  • Pharmacology
  • Animal Behavior

Background:

  • Two-bottle choice home cage drinking is a standard method for studying ethanol consumption in rodents.
  • Traditional methods offer limited data resolution, measuring intake only once daily.
  • Advanced lickometer systems provide high-resolution, lick-by-lick data but were often mouse-specific.

Purpose of the Study:

  • To review standard and lickometer-equipped two-bottle choice home cage drinking procedures.
  • To introduce methods for adapting the open-source LIQ HD lickometer system for use in rats.
  • To enable parallel, high-resolution analysis of ethanol intake patterns in multiple rats.

Main Methods:

  • Review of established two-bottle choice home cage drinking protocols.
  • Hardware modifications to the LIQ HD system for rat housing (larger cages).
  • Development of a 3D-printed bottle holder compatible with standard rat water bottles.

Main Results:

  • Successful adaptation of the LIQ HD lickometer system for use in rats.
  • Enables simultaneous, high-resolution measurement of ethanol intake in multiple animals.
  • Provides researchers with flexibility to choose between standard or lickometer-equipped setups.

Conclusions:

  • The adapted LIQ HD system offers an affordable and user-friendly solution for studying ethanol consumption in rats.
  • This method significantly increases data resolution for alcohol intake studies in preclinical research.
  • Facilitates detailed interrogation of neurobiological mechanisms underlying alcohol drinking behavior.