Related Experiment Video
Updated: Jun 23, 2026
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
12.6K
Case Report: Activated B-cell-diffuse large B-cell lymphoma
Padmashri Kalmegh1, Alka Hande1, Madhuri Gawande1
1Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, 442004, India.
F1000Research
|August 2, 2024
Summary
Oropharyngeal lymphoma, a rare head and neck cancer, presents diagnostic challenges. This case highlights diffuse large B-cell lymphoma, emphasizing the need for immunohistochemistry for accurate diagnosis and improved patient outcomes.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Lymphomas are tumors of the lymphoreticular system, with Hodgkin's and non-Hodgkin's lymphoma (NHL) being the two main types.
- Oropharyngeal lymphomas are uncommon, posing diagnostic challenges due to diverse histological subtypes.
- Non-Hodgkin's lymphoma (NHL) is the third most frequent tumor in the head and neck region.
Observation:
- A case report details a female patient with a 2-3 month history of palatal swelling.
- An ulceroproliferative lesion was observed on the posterior palate.
- Initial incisional biopsy suggested reactive lymphadenitis, necessitating further investigation.
Findings:
- Punch biopsy and immunohistochemical studies confirmed activated B-cell-diffuse large B-cell lymphoma.
- Diffuse large B-cell lymphoma is the most common type of malignant lymphoma.
- Molecular pathophysiology of this disease has seen significant recent advancements.
Implications:
- Accurate diagnosis of oropharyngeal lymphoma requires correlation of clinical presentation, histology, and immunohistochemistry.
- Early detection and diagnosis are crucial for improving patient prognosis.
- Understanding the molecular aspects of diffuse large B-cell lymphoma can guide treatment strategies.
Related Concept Videos
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...