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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

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Related Experiment Video

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Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

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Case report: Dezocine's rapid and sustained antidepressant effects.

Han Wang^1,2, Nan Lyu^1,2, Qian Zhao^1,3

¹Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Frontiers in Pharmacology

|August 2, 2024

Summary

Opioid receptor modulators show promise for treating depression, especially anhedonia. A case study found a low dose of dezocine rapidly improved depressive symptoms when other treatments failed.

Keywords:

anhedonia case dezocine major depressive disorder opioid

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Area of Science:

Neuroscience
Pharmacology
Psychiatry

Background:

Anhedonia and motivational deficits are core symptoms of depression, often poorly responsive to standard antidepressants.
Opioid receptor modulators are being investigated for their potential to treat depression, anxiety, and anhedonia.

Observation:

A patient with treatment-resistant depression, including significant anhedonia and motivational issues, did not respond to sustained bupropion treatment.
The patient received a single, low-dose intravenous injection of dezocine, a synthetic opioid typically used for pain relief.

Findings:

Dezocine administration led to rapid and sustained improvement in the patient's depressive symptoms.
Notably, the amelioration specifically targeted anhedonia and motivational deficits, core symptoms that were previously unresponsive.

Implications:

This case suggests dezocine may have novel antidepressant properties, particularly for symptoms resistant to conventional therapies.
Further research into opioid receptor modulators like dezocine could offer new therapeutic avenues for major depressive disorder.