Association between the systemic immune-inflammation index and erectile dysfunction: A cross-sectional study.

Area of Science:

• Urology
• Immunology
• Public Health

Background:

• Erectile dysfunction (ED) is increasingly recognized as having an inflammatory component.
• The systematic immune-inflammation index (SII) is a novel marker for systemic inflammation.
• Previous research has not investigated the association between SII and ED.

Purpose of the Study:

• To investigate the association between the systematic immune-inflammation index (SII) and the risk of erectile dysfunction (ED).

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2001-2004.
• Employed weighted multivariate regression and restricted cubic spline (RCS) analyses to assess the relationship between SII and ED.
• Conducted subgroup analyses based on age, BMI, hypertension, diabetes, and cardiovascular disease.

Main Results:

• A higher SII (Q4) was associated with an increased risk of ED (OR=1.03, p=.03).
• SII demonstrated a nonlinear association with ED risk, with an inflection point at 485.530.
• Elevated SII (>485.530) correlated with higher ED risk in subgroups aged ≥50, with hypertension, and without diabetes.

Conclusions:

• In US adults, an SII > 485.530 is associated with an increased risk of ED.
• No significant association was found between SII and the risk of severe ED.
• Further research is warranted to validate these findings.