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Related Concept Videos

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Related Experiment Video

Updated: May 5, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Alterations in Gray Matter Structural Networks in Amnestic Mild Cognitive Impairment: A Source-Based Morphometry

Tania M Setiadi1, Jan-Bernard C Marsman1, Sander Martens1

  • 1Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Journal of Alzheimer'S Disease : JAD
|August 2, 2024
PubMed
Summary

Amnestic mild cognitive impairment (aMCI) shows altered brain gray matter volume (GMV) in widespread networks. This study used source-based morphometry to reveal these structural differences in aMCI patients compared to controls.

Keywords:
Alzheimer’s diseaseamnestic mild cognitive impairmentmagnetic resonance imagingsource-based morphometrystructural network

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Imaging

Background:

  • Amnestic mild cognitive impairment (aMCI) is a precursor to Alzheimer's disease, marked by memory deficits and brain gray matter volume (GMV) changes.
  • Prior research on aMCI primarily used univariate voxel-based morphometry for structural MRI analysis.

Purpose of the Study:

  • To investigate structural network differences in aMCI using source-based morphometry, a multivariate approach.
  • To compare brain structure between aMCI patients and cognitively normal older adults.

Main Methods:

  • Structural MRI and neuropsychological assessments were conducted on 91 aMCI patients and 80 controls.
  • Source-based morphometry was employed to estimate spatially independent components (ICs) and analyze covariance.
  • Multivariate analysis of covariance controlled for age, sex, education, and site.

Main Results:

  • aMCI patients displayed reduced GMV in precentral, temporo-cerebellar, frontal, and temporal networks.
  • Increased GMV was observed in the left superior parietal network in aMCI patients.
  • Diagnosis moderated the relationship between the occipital network and Mini-Mental State Examination scores in aMCI.

Conclusions:

  • GMV alterations in temporo-fronto-parieto-cerebellar networks are evident in aMCI.
  • These findings expand upon previous univariate analyses of brain structure in aMCI.