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Updated: Jun 9, 2026
10:03
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
7.2K
[Meningococcal meningitis in Chile between 1990 and 2019]
Darío Vergara Salazar1, Marcela Cárcamo Ibaceta2, María Teresa Valenzuela Bravo3
1Clínica BUPA Reñaca, Viña del Mar, Chile.
Andes Pediatrica : Revista Chilena De Pediatria
|August 2, 2024
Summary
Neisseria meningitidis outbreaks in Chile show a shift in serogroups, with serogroup W becoming more prevalent. This change in 2012 led to fewer meningitis cases but increased meningococcemia and mortality from invasive meningococcal disease (IMD).
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Neisseria meningitidis outbreaks have occurred in Chile since 1941, with variations in clinical presentation, incidence, and serogroup prevalence.
- Understanding the epidemiological profile of Neisseria meningitidis is crucial for public health interventions.
Purpose of the Study:
- To summarize evidence on the epidemiological profile of acute bacterial meningitis caused by Neisseria meningitidis in Chile.
- To analyze the incidence of Neisseria meningitidis meningitis between 1990 and 2019.
Main Methods:
- A systematized review of primary articles was conducted following Cochrane Collaboration standards.
- Data sources included PubMed, Scielo, and LILACS, focusing on descriptive studies of Neisseria meningitidis meningitis in English and Spanish.
- Studies on vaccine effectiveness and diagnostic techniques were excluded.
Main Results:
- Evidence between 1990-2019 focused on 2012, with 133 invasive meningococcal disease (IMD) cases reported, 42 of which were meningitis.
- Serogroup W135 strains caused 21.7% of IMD cases with meningitis, while Non-W135 strains accounted for 67.4%.
- Lethality was higher for IMD caused by serogroup W135 (26.7%) compared to Non-W135 (13.9%).
Conclusions:
- The year 2012 marked a shift in prevalent serogroups from B to W.
- This serogroup change was associated with a decrease in meningitis cases but an increase in meningococcemia and overall IMD lethality.
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