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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Special Features of Adaptive Immunity01:20

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Development of Immunocompetence01:22

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Flow Cytometric Characterization of Murine B Cell Development
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Immature B cell homing shapes human lymphoid tissue structure and function.

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  • 1Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.

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Summary

Newly formed human B cells differentiate into two subsets with distinct IgM levels and migration patterns. Differential tissue homing of these immature B cell subsets shapes human lymphoid tissue structure and function.

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Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Newly emerged human B cells transition from bone marrow.
  • These transitional B cells diverge into distinct developmental pathways.
  • These pathways are characterized by differing IgM expression and migratory behaviors.

Purpose of the Study:

  • To investigate the role of differential tissue homing in immature B cell subsets.
  • To understand how these subsets contribute to human lymphoid tissue structure and function.

Main Methods:

  • Analysis of B cell differentiation pathways.
  • Assessment of IgM expression levels in B cell subsets.
  • Evaluation of migratory biases in immature human B cells.
  • Investigation of tissue homing properties.

Main Results:

  • Identification of two distinct immature B cell subsets post-transitional stage.
  • Characterization of differential IgM expression between subsets.
  • Observation of divergent migratory patterns correlating with tissue homing.
  • Evidence suggesting these homing differences influence lymphoid tissue organization.

Conclusions:

  • Immature human B cell subsets exhibit distinct homing properties based on IgM levels and migration.
  • Differential tissue homing is a key mechanism shaping human lymphoid tissue architecture.
  • This process is crucial for the overall function of the immune system.