Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
Autoimmune Disorders01:29

Autoimmune Disorders

404
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
404

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world treatment patterns and determinants of therapy in systemic sclerosis: findings from the German Network for SSc cohort.

Arthritis research & therapy·2026
Same author

The Nobel Prize honours the discovery of the natural barrier against autoimmunity - a breakthrough in tolerance reconstitution: how far are we from clinical impact?

EULAR rheumatology open·2026
Same author

Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model.

Frontiers in immunology·2026
Same author

Real-World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity-Matched Study From the EUSTAR Cohort.

Arthritis care & research·2026
Same author

Anti-Ro/SSA and rheumatoid factor antibodies are associated with more severe lung involvement in patients with systemic sclerosis: a study from the EUSTAR database.

European journal of internal medicine·2026
Same author

Zeitschrift fur Rheumatologie·2026

Related Experiment Video

Updated: Jun 18, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.8K

[Update on systemic sclerosis].

Gabriela Riemekasten1, Ulf Müller-Ladner2

  • 1Klinik für Rheumatologie und Klinische Immunologie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Forschungszentrum Borstel, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck Deutschland, Deutschland. gabriela.riemekasten@uksh.de.

Zeitschrift Fur Rheumatologie
|August 2, 2024
PubMed
Summary

Recent research advances systemic sclerosis (SSc) understanding, offering new insights into pathogenesis and treatment. This overview supplements current guidelines with practical information on SSc management.

Keywords:
Cardiac involvementGastrointestinal involvementGuidelinesRecommendationsTreatment

More Related Videos

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.1K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

412

Related Experiment Videos

Last Updated: Jun 18, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.8K
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.1K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

412

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • European and German guidelines for systemic sclerosis (SSc) treatment are forthcoming.
  • Existing guidelines may not cover recent findings published after literature reviews.
  • There is a need for updated information on SSc manifestations and treatments.

Purpose of the Study:

  • To review recent publications (last year) relevant to systemic sclerosis.
  • To provide practical, up-to-date information supplementing existing guidelines.
  • To highlight key findings in SSc pathogenesis, manifestations, and treatment.

Main Methods:

  • Literature review of publications from the past year.
  • Focus on studies relevant to clinical practice and guideline supplementation.
  • Synthesis of findings on SSc pathogenesis, cardiac and lung involvement, and treatment options.

Main Results:

  • Improved understanding of SSc pathogenesis, including environmental factors and autoantibodies.
  • New insights into cardiac involvement and prognosis in SSc.
  • First guidelines for treating interstitial lung disease in SSc issued by the American Thoracic Society.
  • Evidence supporting combination therapies like rituximab and mycophenolate mofetil (MMF).
  • Inflammatory changes identified as common in joint involvement.
  • Current treatment options for gastrointestinal manifestations presented.

Conclusions:

  • Systemic sclerosis diagnosis and treatment are advancing.
  • Many SSc symptoms and complications are becoming treatable.
  • Further research is needed to enhance patient quality of life.