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Dream of the Endless: Updates in Agents for Procedural Sedation

Abby M Bailey1, Kyle A Weant

  • 1Departments of Emergency Medicine Clinical Pharmacy, Emergency Medicine, and Pharmacy, University of Kentucky HealthCare, Lexington, Kentucky (Dr. Bailey); and Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina (Dr. Weant).

Advanced Emergency Nursing Journal
|August 2, 2024
PubMed

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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