[Hepatitis C: From diagnosis to global virus elimination]

Area of Science:

• Hepatology
• Infectious Diseases
• Public Health

Background:

• Chronic hepatitis C virus (HCV) infection is a major global health concern, leading to liver cirrhosis and hepatocellular carcinoma (HCC).
• The advent of direct-acting antiviral agents (DAAs) has transformed HCV treatment, offering a safe and highly effective cure.

Purpose of the Study:

• To outline the global and national strategies for hepatitis C elimination by 2030.
• To emphasize the importance of identifying and treating undiagnosed HCV cases.
• To highlight the need for targeted interventions for at-risk populations.

Main Methods:

• Review of current HCV treatment guidelines and public health initiatives.
• Analysis of the impact of direct-acting antiviral agents (DAAs) on HCV eradication.
• Discussion of strategies for case finding and treatment adherence.

Main Results:

• HCV infection is curable with DAAs, representing a significant breakthrough in treatment.
• The World Health Organization (WHO) and German government have set ambitious HCV elimination goals for 2030.
• Effective strategies include identifying undiagnosed cases and treating at-risk populations.

Conclusions:

• Achieving HCV elimination by 2030 is feasible with current curative treatments.
• Identifying and treating all HCV cases, particularly in vulnerable groups, is crucial for success.
• Continued public health efforts and micro-elimination projects are essential for global HCV eradication.