Related Experiment Video
Updated: Jun 18, 2025
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Digital retinoblastoma documentation supports care and research
Brenda L Gallie1, Kaitlyn Flegg2, Tran Truong3
1Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON; International Retinoblastoma Consortium; Princess Margaret Cancer Center/University Health Network, Toronto, ON; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON; Temerty Faculty of Medicine, University of Toronto, Toronto, ON..
Digital drawings and timelines for retinoblastoma care have evolved from paper to advanced digital platforms. The new DEPICT system offers global access to digital retinoblastoma care, enhancing patient and family involvement.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Digital Health
Background:
- Historically, retinoblastoma documentation relied on manual methods like colored pencils.
- The eCancerCareRB (eCCRB) system at SickKids introduced digital drawings and timelines to improve patient care, education, and research.
- This digital approach marked a significant advancement over traditional paper-based records.
Purpose of the Study:
- To evaluate the effectiveness of the eCancerCareRB (eCCRB) system in managing retinoblastoma.
- To introduce and assess the capabilities of the new DEPICT HEALTH (DEPICT) system for global digital retinoblastoma care.
- To demonstrate the evolution of digital tools in pediatric cancer management.
Main Methods:
- Utilized the eCCRB timeline to track patient treatments and dates.
- Employed the SwimmerRB tool to analyze eCCRB data, identifying tumor recurrence and treatment effectiveness.
- Developed a "consequence" scoring system for standard retinoblastoma treatments to quantify outcomes.
Main Results:
- The eCCRB system included 700 retinoblastoma patients treated between 2001 and 2023.
- SwimmerRB analysis compared different intra-arterial chemotherapy regimens and treatment effectiveness.
- The study laid the groundwork for the cloud-based DEPICT system, poised to replace the outdated eCCRB.
Conclusions:
- eCCRB served as a successful prototype for the cloud-based DEPICT system.
- DEPICT aims to provide comprehensive digital retinoblastoma care globally, empowering families as partners.
- DEPICT will be accessible through the International Retinoblastoma Consortium for worldwide implementation.
