Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basement membranes in cancer.

F T Bosman, M Havenith, J P Cleutjens

    Ultrastructural Pathology
    |January 1, 1985
    PubMed
    Summary

    Basement membrane integrity is crucial in cancer diagnosis. Immunocytochemistry for basement membrane components aids in distinguishing invasive from non-invasive tumors and classifying soft tissue neoplasms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tuning biological processes <i>via</i> co-solutes: from single proteins to protein condensates - the case of α-elastin condensation.

    Chemical science·2025
    Same author

    Wrapping Up Hydrophobic Hydration: Locality Matters.

    The journal of physical chemistry letters·2020
    Same author

    Integration of a rapid scanning technique into THz time-domain spectrometers for nonlinear THz spectroscopy measurements.

    AIP advances·2019
    Same author

    Cation-specific interactions of protein surface charges in dilute aqueous salt solutions: a combined study using dielectric relaxation spectroscopy and Raman spectroscopy.

    Physical chemistry chemical physics : PCCP·2018
    Same author

    Pilot study demonstrates that placental histology can provide an additional tool for diagnosing early-onset neonatal sepsis.

    Acta paediatrica (Oslo, Norway : 1992)·2018
    Same author

    A novel set-up to investigate the low-frequency spectra of aqueous solutions at high hydrostatic pressure.

    The Review of scientific instruments·2016

    Area of Science:

    • Biopathology
    • Cancer Research
    • Histopathology

    Background:

    • Basement membranes are essential supportive structures in various tissues.
    • Alterations in basement membranes are observed in invasive cancers, with neoplastic cells often lacking a continuous basal lamina.
    • This loss may result from tumor cell collagenase production or impaired basement membrane component synthesis.

    Purpose of the Study:

    • To investigate the role of basement membranes in cancer diagnostics.
    • To evaluate the utility of immunocytochemical staining for basement membrane components.
    • To correlate basement membrane expression with tumor characteristics and differentiation.

    Main Methods:

    • Electron microscopy was used to study basement membranes in neoplasms.
    • Immunocytochemical staining for basement membrane components like type IV collagen and laminin was employed.
    • Correlation analysis was performed between basement membrane staining and tumor invasiveness, differentiation, and origin.

    Main Results:

    • Immunocytochemistry can differentiate non-invasive from invasive lesions by detecting basement membrane continuity.
    • Loss of continuous basement membrane is characteristic of invasive carcinomas.
    • Basement membrane staining patterns help distinguish between basement membrane-producing and non-producing soft tissue tumors.

    Conclusions:

    • Immunocytochemical detection of basement membrane components is valuable in histopathological diagnosis.
    • It aids in distinguishing benign, in situ, and invasive neoplastic lesions.
    • Basement membrane analysis assists in classifying soft tissue tumors based on their origin and production capabilities.

    Related Experiment Videos