Analysis of postoperative weight loss associated with prognosis after sublobar resections for lung cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Significant weight loss after sublobar resection for lung cancer indicates a poor prognosis. Long-term nutritional support is crucial for high-risk patients undergoing this procedure.
Area Of Science
- Thoracic Surgery
- Surgical Oncology
- Pulmonary Medicine
Background
- Sublobar resections for lung cancer are increasingly performed globally.
- The prognostic impact of post-operative weight loss following these procedures remains under-investigated.
Purpose Of The Study
- To evaluate the prognostic significance of weight loss after sublobar resection in non-small cell lung cancer patients.
- To identify risk factors and timing associated with significant post-operative weight loss.
Main Methods
- Analysis of 147 patients who underwent sublobar resection for non-small cell lung cancer (January 2016 - June 2021).
- Weight change was assessed at 3, 6, and 12 months post-surgery.
- Patients were categorized based on ≥5% weight loss, a criterion for frailty, to determine prognostic impact.
Main Results
- 26.5% of patients experienced ≥5% weight loss within one year post-surgery.
- ≥5% weight loss within one year was a significant predictor of poor overall survival and recurrence-free survival (p<0.05).
- Weight loss of ≥5% between 6-12 months post-surgery was linked to poorer outcomes; an age-adjusted Charlson comorbidity index ≥4 predicted this (OR 3.920, p=0.023).
Conclusions
- Postoperative weight loss of ≥5% at 6-12 months is associated with a worse prognosis after sublobar resection.
- Emphasizes the importance of long-term nutritional management in the treatment strategy for high-risk patients undergoing sublobar resection for lung cancer.
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