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[Thrombocyte replacement in hematologic diseases].

P Höcker

    Wiener Klinische Wochenschrift
    |November 22, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study outlines a platelet support strategy for acute leukemia, bone marrow transplant, and antithymocyte globulin patients. The approach achieved a low 3% hemorrhage mortality rate despite aggressive treatments.

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    Quality of packed red blood cells and platelet concentrates collected by multicomponent collection using the MCS plus device.

    Journal of clinical apheresis·2003

    Area of Science:

    • Hematology
    • Transfusion Medicine

    Context:

    • Acute leukemia patients undergoing remission induction therapy
    • Patients undergoing bone marrow transplantation (BMT)
    • Patients treated with antithymocyte globulin (ATG)

    Purpose:

    • To present an effective platelet support strategy for high-risk patient groups.
    • To evaluate the efficacy of platelet transfusions based on specific clinical indications.
    • To determine the platelet concentrate requirements for different patient cohorts.

    Summary:

    • Platelet concentrates were generated via single-donor apheresis, yielding 3.0-4.0 x 10^11 platelets per procedure.
    • Transfusions were administered prophylactically at platelet counts of approximately 20 x 10^9/L and therapeutically below 80 x 10^9/L for procedures.

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  • Patient cohorts included 84 acute leukemia, 36 BMT, and 6 ATG-treated individuals, with varying platelet needs (8, 4-15, and ~20 concentrates, respectively).

    • Impact:

    • The implemented platelet support strategy resulted in a significantly low 3% mortality rate due to hemorrhage.
    • This strategy demonstrates successful management of bleeding complications in patients undergoing intensive medical treatments.
    • The findings provide valuable insights into optimizing platelet transfusion protocols for immunocompromised and critically ill patients.