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Updated: May 12, 2026
Necropsy-based Wild Fish Health Assessment
Published on: September 11, 2018
Modulatory effects of necroptosis: A potential preventive approach to control diseases in fish
Xiaojing Xia1, Jingjing Li1, Jing Yu2
1College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, PR China.
Abstract:
Necroptosis is a caspase-independent programmed cell death process characterized by morphological similarities to necrosis and the potential to cause significant inflammatory reactions. The initiation, execution, and inhibition of necroptosis involve a complex interplay of various signaling proteins. When death receptors bind to ligands, necroptosis is triggered through the receptor-interacting serine/threonine-protein kinase 1 (RIPK1)/RIPK3/Mixed Lineage Kinase Domain-Like (MLKL) axis, leading to inflammatory reactions in the surrounding tissues. This process encompasses numerous physiological regulatory mechanisms and contributes to the development and progression of certain diseases. The mechanisms of necroptosis were not well conserved across terrestrial and aquatic organisms, with differences in some components and functions. Given the significant challenges that aquatic animal diseases pose to aquaculture, research interest in necroptosis has surged recently, particularly in studies focusing on fish. Understanding necroptosis in fish can lead to interventions that offer potential breakthroughs in disease inhibition and fish health improvement.
Insights
Necroptosis, a programmed cell death pathway, involves RIPK1/RIPK3/MLKL signaling and causes inflammation. Understanding its unique mechanisms in fish is key to improving aquaculture disease resistance and health.
Area of Science:
- Cell Biology
- Immunology
- Aquatic Animal Health
Background:
- Necroptosis is a programmed cell death pathway distinct from apoptosis, characterized by inflammation.
- The RIPK1/RIPK3/MLKL signaling axis mediates necroptosis initiation and execution.
- Necroptosis plays roles in physiological regulation and disease pathogenesis.
Purpose of the Study:
- To explore the mechanisms of necroptosis in aquatic organisms, particularly fish.
- To investigate the differences in necroptosis pathways between terrestrial and aquatic species.
- To identify potential targets for disease intervention in aquaculture.
Main Methods:
- Comparative analysis of necroptosis signaling components across species.
- Investigating the functional roles of RIPK1, RIPK3, and MLKL in fish models.
- Examining the inflammatory consequences of necroptosis induction in fish.
Main Results:
- Necroptosis mechanisms show variations between terrestrial and aquatic organisms.
- The RIPK1/RIPK3/MLKL pathway is conserved but has unique features in fish.
- Necroptosis activation in fish is linked to inflammatory responses relevant to disease.
Conclusions:
- Understanding fish necroptosis is crucial for addressing aquaculture challenges.
- Targeting necroptosis pathways could lead to novel strategies for disease control in fish.
- Further research into fish necroptosis promises advancements in aquatic animal health and disease management.
