Related Experiment Video
Updated: Jun 18, 2025
09:40
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
2.6K
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer
Qianxin Xie1, Jie Zhou1, Chaonan He1
1Department of Immunology and Microbiology, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Critical Reviews in Oncology/Hematology
|August 3, 2024
Summary
Platelets significantly contribute to ovarian cancer progression and metastasis by interacting with tumor cells. Targeting these platelet-cancer interactions offers promising therapeutic strategies for managing ovarian cancer and its thrombotic complications.
Area of Science:
- Oncology
- Hematology
- Cancer Biology
Background:
- Ovarian cancer is a highly aggressive malignancy associated with increased thrombotic events.
- Elevated platelet counts and activation are common in ovarian cancer patients.
- Platelets play a crucial role in ovarian cancer progression, including proliferation and metastasis.
Purpose of the Study:
- To review the intricate interactions between platelets and ovarian cancer cells.
- To emphasize the dual role of platelets in tumor progression and thrombotic events.
- To summarize emerging therapeutic strategies targeting the platelet-cancer interface.
Main Methods:
- Literature review of scientific articles and research studies.
- Analysis of the mechanisms by which platelets influence ovarian cancer.
- Synthesis of current and future therapeutic approaches.
Main Results:
- Platelets enhance ovarian cancer cell proliferation, angiogenesis, and metastasis.
- Platelet-cancer cell interactions contribute to the high thrombotic risk in ovarian cancer.
- Therapeutic strategies targeting platelet functions show potential in preclinical studies.
Conclusions:
- Platelets are key players in ovarian cancer pathogenesis and thrombotic complications.
- Targeting platelet-cancer interactions presents a promising avenue for novel ovarian cancer therapies.
- Interventions aimed at the platelet-cancer interface may improve treatment outcomes and reduce metastasis and thrombosis.
Related Concept Videos
01:22Formation of the Platelet Plug
5.5K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.5K
02:07Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
502
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
502
01:18Structure and Function of Platelets
1.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.1K
01:17Intracellular Signaling Affects Focal Adhesions
2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.6K