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PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1

Yuichiro Nakata1, Shion Nagasawa2, Yasuyuki Sera3

  • 1Department of Systems Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8670, Japan. nakatay@chiba-u.jp.

Scientific Reports
|August 3, 2024
PubMed
Summary

The PTIP-PRDM1 axis is crucial for DNA damage repair and cell cycle regulation. Its downregulation in acute myeloid leukemia patients suggests a role in leukemogenesis.

Keywords:
DNA damage responseH3K4me3Histone methylationPTIP

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