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Updated: Jun 18, 2025

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
Published on: July 20, 2022
Incidence and risk factors of complications during central venous access devices removal in children
Sue Liu1, Ramesh M Nataraja1,2,3, Amiria Lynch3
1Department of Paediatrics, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Insights
Complications during central venous access device (CVAD) removal in children occur in nearly 10% of cases. Longer indwelling times, especially over 2 years, significantly increase the risk of difficult CVAD removal.
Area of Science:
- Pediatric Medicine
- Medical Devices
- Surgical Complications
Background:
- Central venous access devices (CVADs) are crucial for long-term therapy in pediatric patients.
- Complications during CVAD removal can lead to patient distress and increased healthcare costs.
Purpose of the Study:
- To determine the incidence of complications during central venous access device removal in children.
- To identify risk factors associated with difficult CVAD removal in pediatric patients.
Main Methods:
- Retrospective analysis of 208 CVAD removals in children from 2018-2023.
- Logistic regression and ROC curve analysis were employed to identify risk factors and optimal cut-offs for indwelling time.
Main Results:
- Approximately 9.6% of CVAD removals were complicated by difficulty.
- Children with acute lymphoblastic leukemia (ALL) and longer indwelling times (>2.09 years) had a significantly higher risk of complicated removal.
- An indwelling time exceeding 2.09 years was associated with a 2.87-fold increased risk of difficult removal.
Conclusions:
- Nearly 10% of pediatric CVAD removals are associated with complications.
- Longer indwelling times (>2 years) are a significant risk factor for complicated CVAD removal.
- Preventive strategies should be considered for children with long-term central venous access to mitigate removal complications.
Purpose:
To quantify the rates and identify risk factors for the complications of central venous access devices (CVADs) removal in children.
Method:
Retrospective (2018-2023) review of children undergoing CVADs removal at a single institution. Data are reported as frequency, percentages and median. Logistic regression analysis was used to identify risk factors associated with difficult removal. Receiver Operating Characteristic Curve (ROC) analysis was conducted to identify the age cut-off and positive likelihood ratio (+LH) for the indwelling time associated with complicated removal. p-Value <0.05 were considered statistically significant.
Results:
We identified 208 CVAD removals with a median age of 7.2 (0.2-18.4) years including 116 (55.8%) males. The median CVAD placement duration was 1.26 years (0.4-5.7) years. Indications for insertion included acute lymphoblastic leukaemia (ALL; 78/208, 37.5%), lymphomas (31/208, 14.9%), other malignancies (58/208, 27.9%). Removal indications included completion of treatment (144/208, 69.2%), infection (22/208, 10.6%), malfunction (7/208, 3.4%) and other reasons (35/208, 16.8%). There were 20 (9.6%) complications characterised by difficulty removing the CVAD. Complicated removals were more likely to occur in children with ALL as the primary diagnosis (p = 0.001); independently of the indication for insertion, longer indwelling time was associated with higher risk of complicated removal (p < 0.001). Indwelling time >2.09 years was associated with a 2.87 increased risk of difficult removal.
Conclusion:
In our experience, almost 10% of CVAD removals in children result in complications. These findings are associated with an indwelling time >2 years; strategies to prevent complicated removals should be considered in children requiring long-term central venous access.
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