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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Related Experiment Video

Updated: Jun 18, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Senotherapy preserves resilience in aging.

Takumi Mikawa1,2, Kazumichi Yoshida3, Hiroshi Kondoh1

  • 1Geriatric Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Geriatrics & Gerontology International
|August 4, 2024
PubMed
Summary
This summary is machine-generated.

Senotherapy, using senolytics or senostatics, offers novel strategies to combat aging-related diseases by targeting senescent cells and inflammation. These approaches aim to improve resilience and reduce the burden of age-related conditions.

Keywords:
resiliencesenescence‐associated secretor phenotypesenolysissenostaticssenotherapy

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Area of Science:

  • Gerontology and aging research.
  • Cellular biology and senescence.
  • Inflammation and disease mechanisms.

Background:

  • Aging societies face increasing social and economic burdens from age-related diseases.
  • Reduced resilience in older adults contributes to functional decline and multimorbidity.
  • Senescent cells accumulate with age, exacerbating inflammation and disease.

Purpose of the Study:

  • To explore senotherapy as a novel strategy for managing aging-related diseases.
  • To investigate the roles of senolytics and senostatics in combating aging.
  • To understand the impact of senotherapy on resilience and inflammation.

Main Methods:

  • Review of senolytic drugs targeting senescent cell apoptosis.
  • Analysis of senostatic interventions, such as calorie restriction, for inflammation.
  • Examination of the link between senescent cells, inflammation, and resilience.

Main Results:

  • Senolytic drugs eliminate senescent cells, reducing inflammatory factor excretion.
  • Senostatic interventions alleviate chronic inflammation associated with aging.
  • Both senolytics and senostatics are expected to reduce sterile inflammation from senescent cells.

Conclusions:

  • Senotherapy presents promising therapeutic avenues for age-related diseases.
  • Targeting senescent cells and inflammation can potentially restore resilience in aging.
  • Further research into senolytics and senostatics is crucial for improving healthspan.