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Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers.

Danyel Chermon1, Ruth Birk1

  • 1Nutrition Department, Health Sciences Faculty, Ariel University, Ariel, Israel.

Journal of Obesity & Metabolic Syndrome
|August 4, 2024
PubMed
Summary

The Src homology 2 B adaptor protein 1 (SH2B1) rs7498665 variant increases obesity risk. Lifestyle factors like physical activity and stress significantly influence this genetic predisposition, offering potential intervention points for obesity management.

Keywords:
ExerciseFeeding behaviorGlucoseObesityPolymorphismSrc homology 2 B adaptor protein 1 gene

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Area of Science:

  • Genetics
  • Metabolic Health
  • Population Health

Background:

  • The Src homology 2 B adaptor protein 1 (SH2B1) gene is linked to common obesity.
  • Specific variants within SH2B1 may influence obesity risk and interact with environmental factors.

Purpose of the Study:

  • To investigate the association between the SH2B1 rs7498665 variant and common obesity risk.
  • To explore interactions between the SH2B1 rs7498665 variant and lifestyle/behavioral factors in an Israeli population.

Main Methods:

  • Analysis of a cohort (n=3,070) with SH2B1 rs7498665 variant data.
  • Assessment of obesity risk (BMI ≥25 and ≥30 kg/m²).
  • Investigation of interactions with stress, eating habits score (EHS), physical activity (PA), wine consumption, and fasting glucose using binary logistic regressions.

Main Results:

  • SH2B1 rs7498665 carriers showed significantly higher odds of being overweight or obese across multiple genetic models.
  • Significant interactions were observed between the rs7498665 variant and lifestyle factors, including PA, wine consumption, stress, EHS, and fasting glucose.
  • Physical activity and moderate wine consumption reduced obesity risk, while high stress, high EHS, and elevated fasting glucose increased risk in variant carriers.

Conclusions:

  • The SH2B1 rs7498665 variant significantly elevates obesity risk.
  • Lifestyle and behavioral factors modulate the genetic predisposition to obesity conferred by SH2B1 rs7498665.
  • PA and moderate wine intake can attenuate obesity risk, whereas high stress, EHS, and fasting glucose exacerbate it.