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Predicting psychosocial intervention response from baseline gene expression.

Itay Ricon-Becker1, Taylor N West2, Barbara L Fredrickson2

  • 1Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

Brain, Behavior, and Immunity
|August 4, 2024
PubMed
Summary
This summary is machine-generated.

Baseline gene expression, specifically CREB activity, can predict psychological responses to compassion meditation. This finding suggests gene profiles may help personalize psychosocial interventions beyond traditional measures.

Keywords:
Clinical PsychologyConserved Transcriptional Response to Adversity (CTRA)Personalized PsychotherapyPsychiatrySocial Genomics

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Area of Science:

  • Psychoneuroimmunology
  • Genomics
  • Psychosocial Interventions

Background:

  • Predicting individual responses to psychosocial interventions remains a challenge.
  • Psychometric measures alone may not capture all relevant predictive factors.
  • Gene expression profiles offer a potential avenue for enhanced prediction.

Purpose of the Study:

  • To investigate if baseline gene expression profiles predict psychological responses to meditation.
  • To determine if gene expression adds predictive value beyond psychometric measures.
  • To explore the role of specific gene regulation pathways in intervention outcomes.

Main Methods:

  • Utilized transcription factor activity inferred from gene expression in blood samples.
  • Analyzed stress-related gene pathways (CREB, GR, NF-ĸB) using TELiS bioinformatic analysis.
  • Applied findings to two randomized controlled trials of compassion-based meditation (CM) and mindfulness meditation (MM).

Main Results:

  • Higher baseline CREB activity predicted greater reductions in loneliness and negative emotions for CM participants.
  • This association was specific to CM and not observed for mindfulness meditation (MM).
  • Baseline CREB activity also predicted increased life satisfaction in CM, independent of psychometric measures.

Conclusions:

  • Pre-intervention gene expression, particularly CREB activity, may reflect non-conscious states influencing intervention outcomes.
  • Gene expression profiles show potential for personalizing the selection of psychosocial interventions.
  • This genomics approach could enhance the efficacy of psychological treatments.