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Updated: Jun 18, 2025
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia
Michela Bardini1, Grazia Fazio1,2, Lilia Corral Abascal1
1Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Abstract:
Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.
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